![]() ![]() A method to map replication domains at the genome-wide level was reported by David Gilbert and colleagues nearly ten years ago. An intriguing fact revealed by the Hi-C experiment that early and late replication domains are largely consistent with A and B compartments of self-interacting chromatin domains suggests that replication domain organization reflects three-dimensional higher-order chromatin folding patterns in the nucleus. Early replication domains are basically characterized as gene-rich euchromatins, while late replication domains are relatively gene-poor and enriched with inactive chromatin marks. ![]() Genomic regions replicated in the first and second half of the S phase are called early and late replication domains, respectively. ![]() DNA replication in mammalian cells is regulated as Mb-sized large chromosomal units called replication domains in which activation of multiple replication origins occurs in a relatively synchronous manner. ![]()
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